Reduced intrinsic DNA curvature leads to increased mutation rate
نویسندگان
چکیده
منابع مشابه
Interference of intrinsic curvature of DNA by DNA-intercalating agents.
It has been demonstrated in our studies that the intrinsic curvature of DNA can be easily interrupted by low concentrations of chloroquine and ethidium bromide. In addition, the changes of DNA curvature caused by varying the concentration of these two DNA intercalators can be readily verified through using an atomic force microscope.
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2018
ISSN: 1474-760X
DOI: 10.1186/s13059-018-1525-y